5N2J
UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum (closed form)
Summary for 5N2J
Entry DOI | 10.2210/pdb5n2j/pdb |
Descriptor | UDP-glucose-glycoprotein glucosyltransferase-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | glycoprotein, misfolding, transferase, endoplasmic reticulum |
Biological source | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) |
Total number of polymer chains | 2 |
Total formula weight | 344147.24 |
Authors | Roversi, P.,Caputo, A.T.,Hill, J.,Alonzi, D.S.,Zitzmann, N. (deposition date: 2017-02-07, release date: 2017-07-26, Last modification date: 2020-07-29) |
Primary citation | Roversi, P.,Marti, L.,Caputo, A.T.,Alonzi, D.S.,Hill, J.C.,Dent, K.C.,Kumar, A.,Levasseur, M.D.,Lia, A.,Waksman, T.,Basu, S.,Soto Albrecht, Y.,Qian, K.,McIvor, J.P.,Lipp, C.B.,Siliqi, D.,Vasiljevic, S.,Mohammed, S.,Lukacik, P.,Walsh, M.A.,Santino, A.,Zitzmann, N. Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. Proc. Natl. Acad. Sci. U.S.A., 114:8544-8549, 2017 Cited by PubMed: 28739903DOI: 10.1073/pnas.1703682114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.4 Å) |
Structure validation
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