5N24

Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide

Summary for 5N24

Entry DOI	10.2210/pdb5n24/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-(4-cyanophenyl)benzenesulfonamide, ... (5 entities in total)
Functional Keywords	lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29963.16
Authors	Ferraroni, M.,Supuran, C.T.,Scozzafava, A.,Carta, F. (deposition date: 2017-02-07, release date: 2017-12-27, Last modification date: 2024-01-17)
Primary citation	Ferraroni, M.,Cornelio, B.,Sapi, J.,Supuran, C.T.,Scozzafava, A. Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms Inorg.Chim.Acta., 470:128-132, 2018 Cited by DOI: 10.1016/j.ica.2017.03.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation