5N1V

Crystal structure of the protein kinase CK2 catalytic subunit in complex with pyrazolo-pyrimidine macrocyclic ligand

Summary for 5N1V

• Entry DOI: 10.2210/pdb5n1v/pdb
• Descriptor: Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P68400
• Total number of polymer chains: 2
• Total formula weight: 84605.93

Authors

Robb, G.,Ferguson, A.,Hargreaves, D. (deposition date: 2017-02-06, release date: 2017-05-17, Last modification date: 2017-06-07)

• Primary citation: McCoull, W.,Abrams, R.D.,Anderson, E.,Blades, K.,Barton, P.,Box, M.,Burgess, J.,Byth, K.,Cao, Q.,Chuaqui, C.,Carbajo, R.J.,Cheung, T.,Code, E.,Ferguson, A.D.,Fillery, S.,Fuller, N.O.,Gangl, E.,Gao, N.,Grist, M.,Hargreaves, D.,Howard, M.R.,Hu, J.,Kemmitt, P.D.,Nelson, J.E.,O'Connell, N.,Prince, D.B.,Raubo, P.,Rawlins, P.B.,Robb, G.R.,Shi, J.,Waring, M.J.,Whittaker, D.,Wylot, M.,Zhu, X.; Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.; J. Med. Chem., 60:4386-4402, 2017; PubMed: 28485934; DOI: 10.1021/acs.jmedchem.7b00359

Experimental method

X-RAY DIFFRACTION (2.52 Å)