5N1R
Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide
Summary for 5N1R
| Entry DOI | 10.2210/pdb5n1r/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | lyase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29759.94 |
| Authors | Ferraroni, M.,Supuran, C.T.,Scozzafava, A.,Carta, F. (deposition date: 2017-02-06, release date: 2017-12-27, Last modification date: 2024-01-17) |
| Primary citation | Ferraroni, M.,Cornelio, B.,Sapi, J.,Supuran, C.T.,Scozzafava, A. Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms Inorg.Chim.Acta., 470:128-132, 2018 Cited by DOI: 10.1016/j.ica.2017.03.038PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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