5N19
Structure of SARS coronavirus main protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide
Summary for 5N19
Entry DOI | 10.2210/pdb5n19/pdb |
Descriptor | SARS coronavirus main protease, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | viral protease, coronavirus, alpha-ketoamide, inhibitor, hydrolase |
Biological source | Human SARS coronavirus (SARS-CoV) |
Cellular location | Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7 |
Total number of polymer chains | 1 |
Total formula weight | 34523.43 |
Authors | Zhang, L.,Ma, Q.,Hilgenfeld, R. (deposition date: 2017-02-05, release date: 2018-02-28, Last modification date: 2024-05-01) |
Primary citation | Lin, D.,Zhang, L.,Kusov, Y.,Nian, Y.,Ma, Q.,Wang, J.,Leyssen, P.,Lanko, K.,Neyts, J.,de Wilde, A.,Snijder, E.J.,Liu, H.,Hilgenfeld, R. Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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