5MZK
Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-[5-chloro-6-(cyclobutylmethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid
Summary for 5MZK
Entry DOI | 10.2210/pdb5mzk/pdb |
Descriptor | Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | kmo, oxidoreductase |
Biological source | Pseudomonas fluorescens |
Total number of polymer chains | 2 |
Total formula weight | 104282.47 |
Authors | Rowland, P. (deposition date: 2017-01-31, release date: 2017-04-19, Last modification date: 2024-05-08) |
Primary citation | Walker, A.L.,Ancellin, N.,Beaufils, B.,Bergeal, M.,Binnie, M.,Bouillot, A.,Clapham, D.,Denis, A.,Haslam, C.P.,Holmes, D.S.,Hutchinson, J.P.,Liddle, J.,McBride, A.,Mirguet, O.,Mowat, C.G.,Rowland, P.,Tiberghien, N.,Trottet, L.,Uings, I.,Webster, S.P.,Zheng, X.,Mole, D.J. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J. Med. Chem., 60:3383-3404, 2017 Cited by PubMed: 28398044DOI: 10.1021/acs.jmedchem.7b00055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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