5MZC

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

5MZC の概要

• エントリーDOI: 10.2210/pdb5mzc/pdb
• 分子名称: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: kmo, oxidoreductase
• 由来する生物種: Pseudomonas fluorescens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104733.63

構造登録者

Rowland, P. (登録日: 2017-01-31, 公開日: 2017-04-19, 最終更新日: 2017-05-10)

• 主引用文献: Walker, A.L.,Ancellin, N.,Beaufils, B.,Bergeal, M.,Binnie, M.,Bouillot, A.,Clapham, D.,Denis, A.,Haslam, C.P.,Holmes, D.S.,Hutchinson, J.P.,Liddle, J.,McBride, A.,Mirguet, O.,Mowat, C.G.,Rowland, P.,Tiberghien, N.,Trottet, L.,Uings, I.,Webster, S.P.,Zheng, X.,Mole, D.J.; Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.; J. Med. Chem., 60:3383-3404, 2017; PubMed: 28398044; DOI: 10.1021/acs.jmedchem.7b00055

実験手法

X-RAY DIFFRACTION (1.82 Å)