5MZ3

P38 ALPHA MUTANT C162S IN COMPLEX WITH CMPD2 [N-(4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl)benzamide]

5MZ3 の概要

• エントリーDOI: 10.2210/pdb5mz3/pdb
• 分子名称: Mitogen-activated protein kinase 14, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide (3 entities in total)
• 機能のキーワード: kinase, inhibitor, phosphotransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42897.79

構造登録者

Cowan-Jacob, S.W.,Scheufler, C. (登録日: 2017-01-30, 公開日: 2017-11-15, 最終更新日: 2018-11-07)

• 主引用文献: Smith, A.,Ni, Z.J.,Poon, D.,Huang, Z.,Chen, Z.,Zhang, Q.,Tandeske, L.,Merritt, H.,Shoemaker, K.,Chan, J.,Kaufman, S.,Huh, K.,Murray, J.,Appleton, B.A.,Cowan-Jacob, S.W.,Scheufler, C.,Kanazawa, T.,Jansen, J.M.,Stuart, D.,Shafer, C.M.; Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.; Bioorg. Med. Chem. Lett., 27:5221-5224, 2017; PubMed: 29107542; DOI: 10.1016/j.bmcl.2017.10.047

実験手法

X-RAY DIFFRACTION (2.15 Å)