5MXV

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution

5MXV の概要

• エントリーDOI: 10.2210/pdb5mxv/pdb
• 分子名称: HTH-type transcriptional regulator EthR, 3-chloranyl-~{N}-(4,5-dihydro-1,3-thiazol-2-yl)-6-fluoranyl-1-benzothiophene-2-carboxamide (3 entities in total)
• 機能のキーワード: ethr, mycobacterium tuberculosis, transcription, represor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25574.04

構造登録者

Blaszczyk, M.,Mendes, V.,Mugumbate, G.,Blundell, T.L. (登録日: 2017-01-24, 公開日: 2017-10-25, 最終更新日: 2024-01-17)

• 主引用文献: Mugumbate, G.,Mendes, V.,Blaszczyk, M.,Sabbah, M.,Papadatos, G.,Lelievre, J.,Ballell, L.,Barros, D.,Abell, C.,Blundell, T.L.,Overington, J.P.; Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.; Front Pharmacol, 8:681-681, 2017; PubMed: 29018348; DOI: 10.3389/fphar.2017.00681

実験手法

X-RAY DIFFRACTION (1.626 Å)