5MWP

The structure of MR in complex with AZD9977.

Summary for 5MWP

• Entry DOI: 10.2210/pdb5mwp/pdb
• Descriptor: Mineralocorticoid receptor, NCOA1 peptide, 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide, ... (4 entities in total)
• Functional Keywords: signaling protein, nuclear hormone receptor, ligand complex, peptide complex
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P08235
• Total number of polymer chains: 2
• Total formula weight: 36932.01

Authors

Edman, K.,Aagaard, A.,Backstrom, S. (deposition date: 2017-01-19, release date: 2018-03-07, Last modification date: 2024-01-17)

• Primary citation: Bamberg, K.,Johansson, U.,Edman, K.,William-Olsson, L.,Myhre, S.,Gunnarsson, A.,Geschwindner, S.,Aagaard, A.,Bjornson Granqvist, A.,Jaisser, F.,Huang, Y.,Granberg, K.L.,Jansson-Lofmark, R.,Hartleib-Geschwindner, J.; Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.; PLoS ONE, 13:e0193380-e0193380, 2018; PubMed: 29474466; DOI: 10.1371/journal.pone.0193380

Experimental method

X-RAY DIFFRACTION (1.82 Å)