5MWA

human sEH Phosphatase in complex with 3-4-3,4-dichlorophenyl-5-phenyl-1,3-oxazol-2-yl-benzoic-acid

5MWA の概要

• エントリーDOI: 10.2210/pdb5mwa/pdb
• 分子名称: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, 3-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]benzoic acid, ... (4 entities in total)
• 機能のキーワード: phosphatase, complex, inhibitor, magnesium, human soluble epoxide hydrolase, seh, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27835.41

構造登録者

Kramer, J.S.,Pogoryelov, D.,Sorrell, F.J.,Fox, N.,Chaikuad, A.,Knapp, S.,Proschak, E. (登録日: 2017-01-18, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

• 主引用文献: Kramer, J.S.,Woltersdorf, S.,Duflot, T.,Hiesinger, K.,Lillich, F.F.,Knoll, F.,Wittmann, S.K.,Klingler, F.M.,Brunst, S.,Chaikuad, A.,Morisseau, C.,Hammock, B.D.,Buccellati, C.,Sala, A.,Rovati, G.E.,Leuillier, M.,Fraineau, S.,Rondeaux, J.,Hernandez Olmos, V.,Heering, J.,Merk, D.,Pogoryelov, D.,Steinhilber, D.,Knapp, S.,Bellien, J.,Proschak, E.; Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain.; J.Med.Chem., 2019; PubMed: 31436984; DOI: 10.1021/acs.jmedchem.9b00445

実験手法

X-RAY DIFFRACTION (1.55 Å)