5MUT

Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds

5MUT の概要

• エントリーDOI: 10.2210/pdb5mut/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
• 機能のキーワード: dhodh, human dhodh, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40857.42

構造登録者

Goyal, P.,Andersson, M.,Moritzer, A.C.,Sainas, S.,Pippione, A.C.,Boschi, D.,Al-Kadaraghi, S.,Lolli, M.,Friemann, R. (登録日: 2017-01-14, 公開日: 2017-03-08, 最終更新日: 2024-01-17)

• 主引用文献: Sainas, S.,Pippione, A.C.,Giorgis, M.,Lupino, E.,Goyal, P.,Ramondetti, C.,Buccinna, B.,Piccinini, M.,Braga, R.C.,Andrade, C.H.,Andersson, M.,Moritzer, A.C.,Friemann, R.,Mensa, S.,Al-Kadaraghi, S.,Boschi, D.,Lolli, M.L.; Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.; Eur J Med Chem, 129:287-302, 2017; PubMed: 28235702; DOI: 10.1016/j.ejmech.2017.02.017

実験手法

X-RAY DIFFRACTION (1.75 Å)