5MU0

ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)

Summary for 5MU0

Entry DOI	10.2210/pdb5mu0/pdb
Descriptor	heavy chain of ACC1 antibody Fab fragment, light chain of ACC1 antibody Fab fragment, IA03 peptide containing the citrullinated C1 epitope of collagen type II,Collagen alpha-1(II) chain,IA03 peptide containing the citrullinated C1 epitope of collagen type II, ... (4 entities in total)
Functional Keywords	anti-citrullinated protein antibody (acpa) fab fragment collagen type ii citrullinated c1 epitope, immune system
Biological source	Mus musculus (House mouse) More
Total number of polymer chains	24
Total formula weight	390033.06
Authors	Dobritzsch, D.,Holmdahl, R.,Ge, C. (deposition date: 2017-01-11, release date: 2017-07-19, Last modification date: 2024-01-17)
Primary citation	Ge, C.,Tong, D.,Liang, B.,Lonnblom, E.,Schneider, N.,Hagert, C.,Viljanen, J.,Ayoglu, B.,Stawikowska, R.,Nilsson, P.,Fields, G.B.,Skogh, T.,Kastbom, A.,Kihlberg, J.,Burkhardt, H.,Dobritzsch, D.,Holmdahl, R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight, 2:-, 2017 Cited by PubMed: 28679953 DOI: 10.1172/jci.insight.93688 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation