5MTX
Dibenzooxepinone inhibitor 12b in complex with p38 MAPK
5MTX の概要
エントリーDOI | 10.2210/pdb5mtx/pdb |
分子名称 | Mitogen-activated protein kinase 14, 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-6~{H}-benzo[c][1]benzoxepine-9-carboxamide, octyl beta-D-glucopyranoside, ... (4 entities in total) |
機能のキーワード | kinase, inhibitor, p38, complex, type 1.5, transferase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 42522.56 |
構造登録者 | |
主引用文献 | Walter, N.M.,Wentsch, H.K.,Buhrmann, M.,Bauer, S.M.,Doring, E.,Mayer-Wrangowski, S.,Sievers-Engler, A.,Willemsen-Seegers, N.,Zaman, G.,Buijsman, R.,Lammerhofer, M.,Rauh, D.,Laufer, S.A. Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. J. Med. Chem., 60:8027-8054, 2017 Cited by PubMed: 28834431DOI: 10.1021/acs.jmedchem.7b00745 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
構造検証レポート
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