5MTS

Complex of FimH lectin with a TazMan (thiazolylaminomannosides) family member known as potent anti-adhesive agent at 2.6 A resolution

5MTS の概要

• エントリーDOI: 10.2210/pdb5mts/pdb
• 分子名称: Protein FimH, [2-[[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]amino]-1,3-thiazol-5-yl]-(4-methyl-2-pyrazin-2-yl-1,3-thiazol-5-yl)methanone, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, crohn's disease
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64024.91

構造登録者

de Ruyck, J.,Bouckaert, J. (登録日: 2017-01-10, 公開日: 2017-03-15, 最終更新日: 2024-01-17)

• 主引用文献: Alvarez Dorta, D.,Chalopin, T.,Sivignon, A.,de Ruyck, J.,Dumych, T.I.,Bilyy, R.O.,Deniaud, D.,Barnich, N.,Bouckaert, J.,Gouin, S.G.; Physiochemical Tuning of Potent Escherichia coli Anti-Adhesives by Microencapsulation and Methylene Homologation.; ChemMedChem, 12:986-998, 2017; PubMed: 28257558; DOI: 10.1002/cmdc.201700061

実験手法

X-RAY DIFFRACTION (2.6 Å)