5MRL

Crystal structure of human monoamine oxidase B (MAO B) in complex with N(Furan2ylmethyl)Nmethylprop2yn1amine (F2MPA)

Summary for 5MRL

Entry DOI	10.2210/pdb5mrl/pdb
Descriptor	Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (~{E})-~{N}-(furan-2-ylmethyl)-~{N}-methyl-prop-1-en-1-amine, ... (4 entities in total)
Functional Keywords	monoamine oxidase, neurodegeneration, inhibitor, enzyme, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	119548.97
Authors	Binda, C.,De Deurwaerdere, P.,Corne, R.,Leone, C.,Valeri, A.,Valoti, M.,Ramsay, R.R.,Fall, Y.,Marco-Contelles, J. (deposition date: 2016-12-23, release date: 2017-01-11, Last modification date: 2024-01-17)
Primary citation	De Deurwaerdere, P.,Binda, C.,Corne, R.,Leone, C.,Valeri, A.,Valoti, M.,Ramsay, R.R.,Fall, Y.,Marco-Contelles, J. Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine. ACS Chem Neurosci, 8:1026-1035, 2017 Cited by PubMed: 27977122 DOI: 10.1021/acschemneuro.6b00377 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation