5MRL

Crystal structure of human monoamine oxidase B (MAO B) in complex with N(Furan2ylmethyl)Nmethylprop2yn1amine (F2MPA)

5MRL の概要

• エントリーDOI: 10.2210/pdb5mrl/pdb
• 分子名称: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (~{E})-~{N}-(furan-2-ylmethyl)-~{N}-methyl-prop-1-en-1-amine, ... (4 entities in total)
• 機能のキーワード: monoamine oxidase, neurodegeneration, inhibitor, enzyme, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119548.97

構造登録者

Binda, C.,De Deurwaerdere, P.,Corne, R.,Leone, C.,Valeri, A.,Valoti, M.,Ramsay, R.R.,Fall, Y.,Marco-Contelles, J. (登録日: 2016-12-23, 公開日: 2017-01-11, 最終更新日: 2024-01-17)

• 主引用文献: De Deurwaerdere, P.,Binda, C.,Corne, R.,Leone, C.,Valeri, A.,Valoti, M.,Ramsay, R.R.,Fall, Y.,Marco-Contelles, J.; Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.; ACS Chem Neurosci, 8:1026-1035, 2017; PubMed: 27977122; DOI: 10.1021/acschemneuro.6b00377

実験手法