5MRH
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1
Summary for 5MRH
Entry DOI | 10.2210/pdb5mrh/pdb |
Descriptor | Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one, ... (5 entities in total) |
Functional Keywords | receptor, vsp10p, sortilin, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 78945.06 |
Authors | Andersen, J.L.,Strandbygaard, D.,Thirup, S. (deposition date: 2016-12-23, release date: 2017-05-17, Last modification date: 2024-01-17) |
Primary citation | Andersen, J.L.,Lindberg, S.,Langgard, M.,Maltas, P.J.,Ronn, L.C.B.,Bundgaard, C.,Strandbygaard, D.,Thirup, S.,Watson, S.P. The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27:2629-2633, 2017 Cited by PubMed: 28462834DOI: 10.1016/j.bmcl.2017.02.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report