5MRH

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1

5MRH の概要

• エントリーDOI: 10.2210/pdb5mrh/pdb
• 分子名称: Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one, ... (5 entities in total)
• 機能のキーワード: receptor, vsp10p, sortilin, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 78945.06

構造登録者

Andersen, J.L.,Strandbygaard, D.,Thirup, S. (登録日: 2016-12-23, 公開日: 2017-05-17, 最終更新日: 2024-01-17)

• 主引用文献: Andersen, J.L.,Lindberg, S.,Langgard, M.,Maltas, P.J.,Ronn, L.C.B.,Bundgaard, C.,Strandbygaard, D.,Thirup, S.,Watson, S.P.; The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.; Bioorg. Med. Chem. Lett., 27:2629-2633, 2017; PubMed: 28462834; DOI: 10.1016/j.bmcl.2017.02.028

実験手法

X-RAY DIFFRACTION (2.5 Å)