5MMN

E. coli DNA Gyrase B 24 kDa ATPase domain in complex with 1-ethyl-3-[8-methyl-5-(2-methyl-pyridin-4-yl)-isoquinolin-3-yl]-urea

5MMN の概要

• エントリーDOI: 10.2210/pdb5mmn/pdb
• 分子名称: DNA gyrase subunit B, 1-ethyl-3-[8-methyl-5-(2-methylpyridin-4-yl)isoquinolin-3-yl]urea (3 entities in total)
• 機能のキーワード: inhibitor, 009, isomerase
• 由来する生物種: Escherichia coli O157:H7
• 細胞内の位置: Cytoplasm : P0AES7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26196.42

構造登録者

Panchaud, P.,Bruyere, T.,Blumstein, A.-C.,Bur, D.,Chambovey, A.,Ertel, E.A.,Gude, M.,Hubschwerlen, C.,Jacob, L.,Kimmerlin, T.,Pfeifer, T.,Prade, L.,Seiler, P.,Ritz, D.,Rueedi, G. (登録日: 2016-12-12, 公開日: 2017-04-26, 最終更新日: 2024-05-08)

• 主引用文献: Panchaud, P.,Bruyere, T.,Blumstein, A.C.,Bur, D.,Chambovey, A.,Ertel, E.A.,Gude, M.,Hubschwerlen, C.,Jacob, L.,Kimmerlin, T.,Pfeifer, T.,Prade, L.,Seiler, P.,Ritz, D.,Rueedi, G.; Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.; J. Med. Chem., 60:3755-3775, 2017; PubMed: 28406299; DOI: 10.1021/acs.jmedchem.6b01834

実験手法

X-RAY DIFFRACTION (1.9 Å)