Crystal structure of CREBBP bromodomain complexed with UT07C

Summary for 5MMG

DescriptorCREB-binding protein, 1-[4-ethoxy-3-[(1-methylsulfonylindol-6-yl)amino]phenyl]ethanone (3 entities in total)
Functional Keywordscrebbp bromodomain, inhibitor, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight14595.79
Zhu, J.,Caflisch, A. (deposition date: 2016-12-09, release date: 2017-12-20, Last modification date: 2018-10-10)
Primary citation
Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A.
Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9:929-934, 2018
PubMed: 30258543 (PDB entries with the same primary citation)
DOI: 10.1021/acsmedchemlett.8b00286
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.162100 0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution