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5ML8

The crystal structure of PDE6D in complex to inhibitor-4

Summary for 5ML8
Entry DOI10.2210/pdb5ml8/pdb
DescriptorRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}4-[(4-chlorophenyl)methyl]-~{N}4-cyclopentyl-~{N}1-(phenylmethyl)-~{N}1-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide (3 entities in total)
Functional Keywordsprenyl binding protein, farnesylated kras, plasma membrane, arl2, lipid binding protein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytosol : O43924
Total number of polymer chains1
Total formula weight17926.03
Authors
Fansa, E.K.,Martin-Gago, P.,Waldmann, H.,Wittinghofer, A. (deposition date: 2016-12-06, release date: 2017-02-01, Last modification date: 2024-01-17)
Primary citationMartin-Gago, P.,Fansa, E.K.,Klein, C.H.,Murarka, S.,Janning, P.,Schurmann, M.,Metz, M.,Ismail, S.,Schultz-Fademrecht, C.,Baumann, M.,Bastiaens, P.I.,Wittinghofer, A.,Waldmann, H.
A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Angew. Chem. Int. Ed. Engl., 56:2423-2428, 2017
Cited by
PubMed: 28106325
DOI: 10.1002/anie.201610957
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

數據於2024-03-27公開中

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