5ML8

The crystal structure of PDE6D in complex to inhibitor-4

5ML8 の概要

• エントリーDOI: 10.2210/pdb5ml8/pdb
• 分子名称: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}4-[(4-chlorophenyl)methyl]-~{N}4-cyclopentyl-~{N}1-(phenylmethyl)-~{N}1-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide (3 entities in total)
• 機能のキーワード: prenyl binding protein, farnesylated kras, plasma membrane, arl2, lipid binding protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytosol : O43924
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17926.03

構造登録者

Fansa, E.K.,Martin-Gago, P.,Waldmann, H.,Wittinghofer, A. (登録日: 2016-12-06, 公開日: 2017-02-01, 最終更新日: 2024-01-17)

• 主引用文献: Martin-Gago, P.,Fansa, E.K.,Klein, C.H.,Murarka, S.,Janning, P.,Schurmann, M.,Metz, M.,Ismail, S.,Schultz-Fademrecht, C.,Baumann, M.,Bastiaens, P.I.,Wittinghofer, A.,Waldmann, H.; A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.; Angew. Chem. Int. Ed. Engl., 56:2423-2428, 2017; PubMed: 28106325; DOI: 10.1002/anie.201610957

実験手法

X-RAY DIFFRACTION (2.6 Å)