5MKS
HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation
Summary for 5MKS
Entry DOI | 10.2210/pdb5mks/pdb |
Descriptor | Heat shock 70 kDa protein 1A, 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate (3 entities in total) |
Functional Keywords | irreversible inhibitor, chaperone, lysine modification |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P0DMV8 |
Total number of polymer chains | 1 |
Total formula weight | 43684.83 |
Authors | Pettinger, J.,Westwood, I.M.,Cronin, N.,Le Bihan, Y.-V.,Van Montfort, R.L.M. (deposition date: 2016-12-05, release date: 2017-03-01, Last modification date: 2024-05-01) |
Primary citation | Pettinger, J.,Le Bihan, Y.V.,Widya, M.,van Montfort, R.L.,Jones, K.,Cheeseman, M.D. An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56:3536-3540, 2017 Cited by PubMed: 28225177DOI: 10.1002/anie.201611907 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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