5MJN
Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide
Summary for 5MJN
| Entry DOI | 10.2210/pdb5mjn/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, 5-[(4-chlorophenyl)methylsulfanyl]thiophene-2-sulfonamide, ... (4 entities in total) |
| Functional Keywords | ca2, ca ii, carbonic anhydrase 2, carbonic anhydrase ii, sulfonamide, lyase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29543.12 |
| Authors | Leitans, J.,Tars, K. (deposition date: 2016-12-01, release date: 2017-12-06, Last modification date: 2024-01-17) |
| Primary citation | Ivanova, J.,Balode, A.,Zalubovskis, R.,Leitans, J.,Kazaks, A.,Vullo, D.,Tars, K.,Supuran, C.T. 5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations. Bioorg. Med. Chem., 25:857-863, 2017 Cited by PubMed: 28024887DOI: 10.1016/j.bmc.2016.11.045 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.17 Å) |
Structure validation
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