5MI6
BtGH84 mutant with covalent modification by MA3 in complex with Thiamet G
Summary for 5MI6
Entry DOI | 10.2210/pdb5mi6/pdb |
Descriptor | O-GlcNAcase BT_4395, (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, ~{N}-(4-ethoxyquinazolin-2-yl)propanamide, ... (6 entities in total) |
Functional Keywords | hydrolase, activator |
Biological source | Bacteroides thetaiotaomicron VPI-5482 |
Total number of polymer chains | 1 |
Total formula weight | 84321.31 |
Authors | Darby, J.F.,Davies, G.J.,Hubbard, R.E. (deposition date: 2016-11-27, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Darby, J.F.,Atobe, M.,Firth, J.D.,Bond, P.,Davies, G.J.,O'Brien, P.,Hubbard, R.E. Increase of enzyme activity through specific covalent modification with fragments. Chem Sci, 8:7772-7779, 2017 Cited by PubMed: 29163914DOI: 10.1039/c7sc01966a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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