5MHQ
CCT068127 in complex with CDK2
Summary for 5MHQ
Entry DOI | 10.2210/pdb5mhq/pdb |
Descriptor | Cyclin-dependent kinase 2, (2~{R},3~{S})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol (3 entities in total) |
Functional Keywords | cell cycle, inhibitor, cdk2, cdk9, cell cycle-inhibitor complex, cell cycle/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 35173.82 |
Authors | Whittaker, S.R.,Barlow, C.,Martin, M.P.,Mancusi, C.,Wagner, S.,Barrie, E.,te Poele, R.,Sharp, S.,Brown, N.,Wilson, S.,Clarke, P.,Walton, M.I.,MacDonald, E.,Blagg, J.,Noble, M.E.M.,Garrett, M.D.,Workman, P. (deposition date: 2016-11-25, release date: 2017-12-20, Last modification date: 2018-03-14) |
Primary citation | Whittaker, S.R.,Barlow, C.,Martin, M.P.,Mancusi, C.,Wagner, S.,Self, A.,Barrie, E.,Te Poele, R.,Sharp, S.,Brown, N.,Wilson, S.,Jackson, W.,Fischer, P.M.,Clarke, P.A.,Walton, M.I.,McDonald, E.,Blagg, J.,Noble, M.,Garrett, M.D.,Workman, P. Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. Mol Oncol, 12:287-304, 2018 Cited by PubMed: 29063678DOI: 10.1002/1878-0261.12148 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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