5MHF

Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin.

5MHF の概要

• エントリーDOI: 10.2210/pdb5mhf/pdb
• 分子名称: Mannosyl-oligosaccharide glucosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: gh63, glucosidase, iminosugar, hydrolase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 362041.79

構造登録者

Hill, J.C.,Caputo, A.T.,Roversi, P.,Zitzmann, N. (登録日: 2016-11-24, 公開日: 2017-12-20, 最終更新日: 2024-04-24)

• 主引用文献: Warfield, K.L.,Alonzi, D.S.,Hill, J.C.,Caputo, A.T.,Roversi, P.,Kiappes, J.L.,Sheets, N.,Duchars, M.,Dwek, R.A.,Biggins, J.,Barnard, D.,Shresta, S.,Treston, A.M.,Zitzmann, N.; Targeting Endoplasmic Reticulum alpha-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.; J.Med.Chem., 2020; PubMed: 32227946; DOI: 10.1021/acs.jmedchem.0c00067

実験手法

X-RAY DIFFRACTION (2.1 Å)