5MHC
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
Summary for 5MHC
Entry DOI | 10.2210/pdb5mhc/pdb |
Descriptor | 14-3-3 protein sigma, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | 14-3-3 p53 c-terminus, antitumor protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28056.82 |
Authors | Andrei, S.,Ottmann, C.,Leysen, S. (deposition date: 2016-11-24, release date: 2017-10-04, Last modification date: 2024-01-17) |
Primary citation | Doveston, R.G.,Kuusk, A.,Andrei, S.A.,Leysen, S.,Cao, Q.,Castaldi, M.P.,Hendricks, A.,Brunsveld, L.,Chen, H.,Boyd, H.,Ottmann, C. Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591:2449-2457, 2017 Cited by PubMed: 28640363DOI: 10.1002/1873-3468.12723 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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