5MGN
Human Sirt6 in complex with activator UBCS38
Summary for 5MGN
Entry DOI | 10.2210/pdb5mgn/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (7 entities in total) |
Functional Keywords | 4-(pyridin-3-yl)-5-((3-(trifluoromethyl)phenyl)sulfonyl)-4, 5-dihydropyrrolo[1, 2-a]quinoxaline, drug, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleoplasm : Q8N6T7 |
Total number of polymer chains | 2 |
Total formula weight | 69956.79 |
Authors | Steegborn, C.,You, W.,Kambach, C. (deposition date: 2016-11-21, release date: 2016-12-28, Last modification date: 2024-01-17) |
Primary citation | You, W.,Rotili, D.,Li, T.M.,Kambach, C.,Meleshin, M.,Schutkowski, M.,Chua, K.F.,Mai, A.,Steegborn, C. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. Engl., 56:1007-1011, 2017 Cited by PubMed: 27990725DOI: 10.1002/anie.201610082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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