5MEV
MCL1 FAB COMPLEX IN COMPLEX WITH COMPOUND 21
Summary for 5MEV
Entry DOI | 10.2210/pdb5mev/pdb |
Related | 5KU9 5MES |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1, Fab Heavy Chain, Fab Light Chain, ... (5 entities in total) |
Functional Keywords | mcl1 fab macrocycle, mcl1-fab_55_c6his, immune system |
Biological source | Mus musculus (Mouse) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 |
Total number of polymer chains | 3 |
Total formula weight | 67630.29 |
Authors | Hargreaves, D. (deposition date: 2016-11-16, release date: 2017-01-18, Last modification date: 2017-03-08) |
Primary citation | Johannes, J.W.,Bates, S.,Beigie, C.,Belmonte, M.,Breen, J.,Cao, S.,Centrella, P.A.,Clark, M.A.,Cuozzo, J.W.,Dumelin, C.E.,Ferguson, A.D.,Habeshian, S.,Hargreaves, D.,Joubran, C.,Kazmirski, S.,Keefe, A.,Lamb, M.L.,Lan, H.,Li, Y.,Ma, H.,Mlynarski, S.,Packer, M.J.,Rawlins, P.,Robbins, D.W.,Shen, H.,Sigel, E.A.,Soutter, H.H.,Su, N.,Trost, D.M.,Wang, H.,Wickson, K.F.,Wu, C.,Zhang, Y.,Zhao, Q.,Zheng, X.,Hird, A. Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors Acs Med.Chem.Lett., 8:239-244, 2017 Cited by PubMed: 28197319DOI: 10.1021/acsmedchemlett.6b00464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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