5MEV

MCL1 FAB COMPLEX IN COMPLEX WITH COMPOUND 21

5MEV の概要

• エントリーDOI: 10.2210/pdb5mev/pdb
• 関連するPDBエントリー: 5KU9 5MES
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1, Fab Heavy Chain, Fab Light Chain, ... (5 entities in total)
• 機能のキーワード: mcl1 fab macrocycle, mcl1-fab_55_c6his, immune system
• 由来する生物種: Mus musculus (Mouse); 詳細
• 細胞内の位置: Membrane ; Single-pass membrane protein : Q07820
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67630.29

構造登録者

Hargreaves, D. (登録日: 2016-11-16, 公開日: 2017-01-18, 最終更新日: 2017-03-08)

• 主引用文献: Johannes, J.W.,Bates, S.,Beigie, C.,Belmonte, M.,Breen, J.,Cao, S.,Centrella, P.A.,Clark, M.A.,Cuozzo, J.W.,Dumelin, C.E.,Ferguson, A.D.,Habeshian, S.,Hargreaves, D.,Joubran, C.,Kazmirski, S.,Keefe, A.,Lamb, M.L.,Lan, H.,Li, Y.,Ma, H.,Mlynarski, S.,Packer, M.J.,Rawlins, P.,Robbins, D.W.,Shen, H.,Sigel, E.A.,Soutter, H.H.,Su, N.,Trost, D.M.,Wang, H.,Wickson, K.F.,Wu, C.,Zhang, Y.,Zhao, Q.,Zheng, X.,Hird, A.; Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors; Acs Med.Chem.Lett., 8:239-244, 2017; PubMed: 28197319; DOI: 10.1021/acsmedchemlett.6b00464

実験手法

X-RAY DIFFRACTION (2.94 Å)