5MAF

Crystal structure of MELK in complex with an inhibitor

Summary for 5MAF

Entry DOI	10.2210/pdb5maf/pdb
Descriptor	Maternal embryonic leucine zipper kinase, DIMETHYL SULFOXIDE, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	kinase, inhibitor, complex, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Peripheral membrane protein : Q14680
Total number of polymer chains	1
Total formula weight	40873.75
Authors	Canevari, G.,Re Depaolini, S.,Casale, E.,Felder, E.,Kuster, B.,Heinzlmeir, S. (deposition date: 2016-11-03, release date: 2017-12-06, Last modification date: 2017-12-13)
Primary citation	Klaeger, S.,Heinzlmeir, S.,Wilhelm, M.,Polzer, H.,Vick, B.,Koenig, P.A.,Reinecke, M.,Ruprecht, B.,Petzoldt, S.,Meng, C.,Zecha, J.,Reiter, K.,Qiao, H.,Helm, D.,Koch, H.,Schoof, M.,Canevari, G.,Casale, E.,Depaolini, S.R.,Feuchtinger, A.,Wu, Z.,Schmidt, T.,Rueckert, L.,Becker, W.,Huenges, J.,Garz, A.K.,Gohlke, B.O.,Zolg, D.P.,Kayser, G.,Vooder, T.,Preissner, R.,Hahne, H.,Tonisson, N.,Kramer, K.,Gotze, K.,Bassermann, F.,Schlegl, J.,Ehrlich, H.C.,Aiche, S.,Walch, A.,Greif, P.A.,Schneider, S.,Felder, E.R.,Ruland, J.,Medard, G.,Jeremias, I.,Spiekermann, K.,Kuster, B. The target landscape of clinical kinase drugs. Science, 358:-, 2017 Cited by PubMed: 29191878 DOI: 10.1126/science.aan4368 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation