5M7T
Structure of human O-GlcNAc hydrolase with PugNAc type inhibitor
Summary for 5M7T
Entry DOI | 10.2210/pdb5m7t/pdb |
Descriptor | Protein O-GlcNAcase, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE (2 entities in total) |
Functional Keywords | human glacoside hydrolase, glcnac, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502 |
Total number of polymer chains | 2 |
Total formula weight | 206764.56 |
Authors | Roth, C.,Chan, S.,Offen, W.A.,Hemsworth, G.R.,Willems, L.I.,King, D.,Varghese, V.,Britton, R.,Vocadlo, D.J.,Davies, G.J. (deposition date: 2016-10-28, release date: 2017-03-29, Last modification date: 2017-08-30) |
Primary citation | Roth, C.,Chan, S.,Offen, W.A.,Hemsworth, G.R.,Willems, L.I.,King, D.T.,Varghese, V.,Britton, R.,Vocadlo, D.J.,Davies, G.J. Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13:610-612, 2017 Cited by PubMed: 28346405DOI: 10.1038/nchembio.2358 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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