5M7M

Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity

Summary for 5M7M

• Entry DOI: 10.2210/pdb5m7m/pdb
• Descriptor: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ZINC ION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: atx, inhibitor, enpp2, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : Q13822
• Total number of polymer chains: 1
• Total formula weight: 102843.92

Authors

Wolhkoning, A.,Fleury, D.,Leonard, P.,Triballeau, N.,Mollat, P.,Vercheval, L. (deposition date: 2016-10-28, release date: 2017-08-30, Last modification date: 2020-07-29)

• Primary citation: Joncour, A.,Desroy, N.,Housseman, C.,Bock, X.,Bienvenu, N.,Cherel, L.,Labeguere, V.,Peixoto, C.,Annoot, D.,Lepissier, L.,Heiermann, J.,Hengeveld, W.J.,Pilzak, G.,Monjardet, A.,Wakselman, E.,Roncoroni, V.,Le Tallec, S.,Galien, R.,David, C.,Vandervoort, N.,Christophe, T.,Conrath, K.,Jans, M.,Wohlkonig, A.,Soror, S.,Steyaert, J.,Touitou, R.,Fleury, D.,Vercheval, L.,Mollat, P.,Triballeau, N.,van der Aar, E.,Brys, R.,Heckmann, B.; Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.; J. Med. Chem., 60:7371-7392, 2017; PubMed: 28731719; DOI: 10.1021/acs.jmedchem.7b00647

Experimental method

X-RAY DIFFRACTION (2.7 Å)