5M6L
Small Molecule inhibitors of IAP
Summary for 5M6L
Entry DOI | 10.2210/pdb5m6l/pdb |
Descriptor | E3 ubiquitin-protein ligase XIAP, ZINC ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | xiap, apoptosis, metal-binding, inhibitor, xiap#1 |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 1 |
Total formula weight | 15174.37 |
Authors | Williams, P.A. (deposition date: 2016-10-25, release date: 2017-05-24, Last modification date: 2024-05-08) |
Primary citation | Tamanini, E.,Buck, I.M.,Chessari, G.,Chiarparin, E.,Day, J.E.H.,Frederickson, M.,Griffiths-Jones, C.M.,Hearn, K.,Heightman, T.D.,Iqbal, A.,Johnson, C.N.,Lewis, E.J.,Martins, V.,Peakman, T.,Reader, M.,Rich, S.J.,Ward, G.A.,Williams, P.A.,Wilsher, N.E. Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). J. Med. Chem., 60:4611-4625, 2017 Cited by PubMed: 28492317DOI: 10.1021/acs.jmedchem.6b01877 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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