5M4I

Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under high-salt conditions

5M4I の概要

• エントリーDOI: 10.2210/pdb5m4i/pdb
• 分子名称: Casein kinase II subunit alpha, 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase ck2, casein kinase 2, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P68400
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40595.14

構造登録者

Niefind, K.,Bischoff, N.,Yarmoluk, S.M.,Bdzhola, V.G.,Golub, A.G.,Balanda, A.O.,Prykhod'ko, A.O. (登録日: 2016-10-18, 公開日: 2017-01-18, 最終更新日: 2024-01-17)

• 主引用文献: Niefind, K.,Bischoff, N.,Golub, A.G.,Bdzhola, V.G.,Balanda, A.O.,Prykhod'ko, A.O.,Yarmoluk, S.M.; Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.; Pharmaceuticals, 10:-, 2017; PubMed: 28085026; DOI: 10.3390/ph10010009

実験手法

X-RAY DIFFRACTION (2.218 Å)