5M2I

Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1

Summary for 5M2I

• Entry DOI: 10.2210/pdb5m2i/pdb
• Descriptor: Tumor necrosis factor, VHH1 (3 entities in total)
• Functional Keywords: human tumor necrosis factor (tnf) llama vhh1, cytokine
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
• Total number of polymer chains: 12
• Total formula weight: 184719.64

Authors

Cambillau, C.,Spinelli, S.,Desmyter, A.,de Haard, H. (deposition date: 2016-10-13, release date: 2017-08-30, Last modification date: 2024-01-17)

• Primary citation: Beirnaert, E.,Desmyter, A.,Spinelli, S.,Lauwereys, M.,Aarden, L.,Dreier, T.,Loris, R.,Silence, K.,Pollet, C.,Cambillau, C.,de Haard, H.; Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.; Front Immunol, 8:867-867, 2017; PubMed: 28824615; DOI: 10.3389/fimmu.2017.00867

Experimental method

X-RAY DIFFRACTION (2.15 Å)