5M2I

Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1

5M2I の概要

• エントリーDOI: 10.2210/pdb5m2i/pdb
• 分子名称: Tumor necrosis factor, VHH1 (3 entities in total)
• 機能のキーワード: human tumor necrosis factor (tnf) llama vhh1, cytokine
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 184719.64

構造登録者

Cambillau, C.,Spinelli, S.,Desmyter, A.,de Haard, H. (登録日: 2016-10-13, 公開日: 2017-08-30, 最終更新日: 2024-01-17)

• 主引用文献: Beirnaert, E.,Desmyter, A.,Spinelli, S.,Lauwereys, M.,Aarden, L.,Dreier, T.,Loris, R.,Silence, K.,Pollet, C.,Cambillau, C.,de Haard, H.; Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.; Front Immunol, 8:867-867, 2017; PubMed: 28824615; DOI: 10.3389/fimmu.2017.00867

実験手法

X-RAY DIFFRACTION (2.15 Å)