5LR6

Crystal Structure of COMT in complex with [3-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone

5LR6 の概要

• エントリーDOI: 10.2210/pdb5lr6/pdb
• 分子名称: Catechol O-methyltransferase, [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1~{H}-pyrazol-3-yl]-(4-phenylpiperazin-1-yl)methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101218.17

構造登録者

Ehler, A.,Lerner, C.,Rudolph, M.G. (登録日: 2016-08-18, 公開日: 2016-08-31, 最終更新日: 2024-05-01)

• 主引用文献: Lerner, C.,Rudolph, M.G.; Crystal Structure of COMT in complex with [3-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone; To be published,

実験手法

X-RAY DIFFRACTION (2.3 Å)