5LQU

Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-[6-(ethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide

5LQU の概要

• エントリーDOI: 10.2210/pdb5lqu/pdb
• 分子名称: Catechol O-methyltransferase, N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ethylaminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxy-benzamide, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase
• 由来する生物種: Rattus norvegicus (Norway Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51010.08

構造登録者

Ehler, A.,Lerner, C.,Ellermann, M.,Rudolph, M.G. (登録日: 2016-08-17, 公開日: 2016-10-05, 最終更新日: 2024-05-01)

• 主引用文献: Lerner, C.,Ellermann, M.,Rudolph, M.G.; Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-[6-(ethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide; To be published,

実験手法

X-RAY DIFFRACTION (1.8 Å)