5LO0

HSP90 WITH indazole derivative

Summary for 5LO0

• Entry DOI: 10.2210/pdb5lo0/pdb
• Related: 4EEH
• Descriptor: Heat shock protein HSP 90-alpha, [2-azanyl-6-[4,5-bis(fluoranyl)-2-(4-methylpiperazin-1-yl)sulfonyl-phenyl]quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone (3 entities in total)
• Functional Keywords: chaperone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 26278.43

Authors

Graedler, U.,Amaral, M.,Schuetz, D. (deposition date: 2016-08-08, release date: 2017-11-29, Last modification date: 2024-01-10)

• Primary citation: Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F.; Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.; J. Med. Chem., 61:4397-4411, 2018; PubMed: 29701469; DOI: 10.1021/acs.jmedchem.8b00080

Experimental method

X-RAY DIFFRACTION (2.3 Å)