5LLM

Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101

5LLM の概要

• エントリーDOI: 10.2210/pdb5llm/pdb
• 分子名称: Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, SODIUM ION, ASPARTIC ACID, ... (4 entities in total)
• 機能のキーワード: excitatory amino acid transporter 1, human glutamate transporter, slc1a3, ucph101, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Multi-pass membrane protein: P43003
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57090.95

構造登録者

Canul-Tec, J.,Assal, R.,Legrand, P.,Reyes, N. (登録日: 2016-07-27, 公開日: 2017-04-19, 最終更新日: 2024-01-10)

• 主引用文献: Canul-Tec, J.C.,Assal, R.,Cirri, E.,Legrand, P.,Brier, S.,Chamot-Rooke, J.,Reyes, N.; Structure and allosteric inhibition of excitatory amino acid transporter 1.; Nature, 544:446-451, 2017; PubMed: 28424515; DOI: 10.1038/nature22064

実験手法

X-RAY DIFFRACTION (3.25 Å)