5LL9

Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide

Summary for 5LL9

Entry DOI	10.2210/pdb5ll9/pdb
Descriptor	Carbonic anhydrase 12, ZINC ION, 4-[2-(benzimidazol-1-yl)ethanoyl]-2-chloranyl-benzenesulfonamide, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: O43570
Total number of polymer chains	4
Total formula weight	122301.01
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2016-07-27, release date: 2017-08-16, Last modification date: 2024-11-06)
Primary citation	Capkauskaite, E.,Linkuviene, V.,Smirnov, A.,Milinaviciute, G.,Timm, D.,Kasiliauskaite, A.,Manakova, E.,Grazulis, S.,Matulis, D. Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases Chemistryselect, 2017 Cited by DOI: 10.1002/slct.201700531 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation