5LKR
Human Butyrylcholinesterase complexed with N-Propargyliperidines
Summary for 5LKR
| Entry DOI | 10.2210/pdb5lkr/pdb |
| Descriptor | Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
| Functional Keywords | alzheimer disease ad butyrylcholinesterase n-propargyliperidines, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 136625.29 |
| Authors | Coquelle, N.,Knez, D.,Colletier, J.P.,Gobec, S. (deposition date: 2016-07-23, release date: 2016-12-14, Last modification date: 2020-07-29) |
| Primary citation | Kosak, U.,Knez, D.,Coquelle, N.,Brus, B.,Pislar, A.,Nachon, F.,Brazzolotto, X.,Kos, J.,Colletier, J.P.,Gobec, S. N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. Bioorg. Med. Chem., 25:633-645, 2017 Cited by PubMed: 27908752DOI: 10.1016/j.bmc.2016.11.032 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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