5LKR

Human Butyrylcholinesterase complexed with N-Propargyliperidines

5LKR の概要

• エントリーDOI: 10.2210/pdb5lkr/pdb
• 分子名称: Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: alzheimer disease ad butyrylcholinesterase n-propargyliperidines, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 136625.29

構造登録者

Coquelle, N.,Knez, D.,Colletier, J.P.,Gobec, S. (登録日: 2016-07-23, 公開日: 2016-12-14, 最終更新日: 2020-07-29)

• 主引用文献: Kosak, U.,Knez, D.,Coquelle, N.,Brus, B.,Pislar, A.,Nachon, F.,Brazzolotto, X.,Kos, J.,Colletier, J.P.,Gobec, S.; N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.; Bioorg. Med. Chem., 25:633-645, 2017; PubMed: 27908752; DOI: 10.1016/j.bmc.2016.11.032

実験手法

X-RAY DIFFRACTION (2.52 Å)