Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5LIX

Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK184

Summary for 5LIX
Entry DOI10.2210/pdb5lix/pdb
DescriptorAldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-chloro-2-[(2,4,6-tribromobenzyl)carbamoyl]phenoxy}acetic acid, ... (5 entities in total)
Functional Keywordsalpha-beta tim barrel, cytosol, aldo-keto reductase, halogenated ligand, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationLysosome : O60218
Total number of polymer chains1
Total formula weight37768.96
Authors
Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Fanfrlik, J.,Kamlar, M.,Vesely, J.,Hobza, P.,Podjarny, A. (deposition date: 2016-07-15, release date: 2016-07-27, Last modification date: 2024-01-10)
Primary citationCousido-Siah, A.,Ruiz, F.X.,Fanfrlik, J.,Gimenez-Dejoz, J.,Mitschler, A.,Kamlar, M.,Vesely, J.,Ajani, H.,Pares, X.,Farres, J.,Hobza, P.,Podjarny, A.D.
IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.
Acs Chem.Biol., 11:2693-2705, 2016
Cited by
PubMed: 27359042
DOI: 10.1021/acschembio.6b00382
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon