5LIW
Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK319
Summary for 5LIW
Entry DOI | 10.2210/pdb5liw/pdb |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[(4-bromo-2,3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid, ... (5 entities in total) |
Functional Keywords | alpha-beta tim barrel, cytosol, aldo-keto reductase, halogenated ligand, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome : O60218 |
Total number of polymer chains | 1 |
Total formula weight | 38047.56 |
Authors | Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Fanfrlik, J.,Kamlar, M.,Vesely, J.,Hobza, P.,Podjarny, A. (deposition date: 2016-07-15, release date: 2016-07-27, Last modification date: 2024-01-10) |
Primary citation | Cousido-Siah, A.,Ruiz, F.X.,Fanfrlik, J.,Gimenez-Dejoz, J.,Mitschler, A.,Kamlar, M.,Vesely, J.,Ajani, H.,Pares, X.,Farres, J.,Hobza, P.,Podjarny, A.D. IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11:2693-2705, 2016 Cited by PubMed: 27359042DOI: 10.1021/acschembio.6b00382 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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