5LIW

Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK319

5LIW の概要

• エントリーDOI: 10.2210/pdb5liw/pdb
• 分子名称: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[(4-bromo-2,3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid, ... (5 entities in total)
• 機能のキーワード: alpha-beta tim barrel, cytosol, aldo-keto reductase, halogenated ligand, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Lysosome : O60218
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38047.56

構造登録者

Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Fanfrlik, J.,Kamlar, M.,Vesely, J.,Hobza, P.,Podjarny, A. (登録日: 2016-07-15, 公開日: 2016-07-27, 最終更新日: 2024-01-10)

• 主引用文献: Cousido-Siah, A.,Ruiz, F.X.,Fanfrlik, J.,Gimenez-Dejoz, J.,Mitschler, A.,Kamlar, M.,Vesely, J.,Ajani, H.,Pares, X.,Farres, J.,Hobza, P.,Podjarny, A.D.; IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.; Acs Chem.Biol., 11:2693-2705, 2016; PubMed: 27359042; DOI: 10.1021/acschembio.6b00382

実験手法

X-RAY DIFFRACTION (1.75 Å)