5LIT

Structure of the DNA duplex d(AAATTT)2 with the potential antiparasitic drug 6XV at 1.25 A resolution

Summary for 5LIT

• Entry DOI: 10.2210/pdb5lit/pdb
• Descriptor: DNA (5'-D(*AP*AP*AP*TP*TP*T)-3'), 4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzamide dihydrochloride, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: all at dna, antiparasitic drug, minor groove binding drug, dna
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 8416.43

Authors

Millan, C.R.,Dardonville, C.,de Koning, H.P.,Saperas, N.,Lourdes Campos, J. (deposition date: 2016-07-15, release date: 2017-06-14, Last modification date: 2024-05-08)

• Primary citation: Millan, C.R.,Acosta-Reyes, F.J.,Lagartera, L.,Ebiloma, G.U.,Lemgruber, L.,Nue Martinez, J.J.,Saperas, N.,Dardonville, C.,de Koning, H.P.,Campos, J.L.; Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.; Nucleic Acids Res., 45:8378-8391, 2017; PubMed: 28637278; DOI: 10.1093/nar/gkx521

Experimental method

X-RAY DIFFRACTION (1.25 Å)